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German doctors use an innovative treatment for serious cases of infection with E. coli

German doctors resort to an innovative treatment for the most serious cases of E. coli bacteria contamination, testing a drug used for years to treat a rare blood disease.

"The first treatment was started with about eight days ago," said French Health Security Agency.

Alexion U.S. laboratory that developed the drug Soliris (eculizumab), refusing to comment on information.

"There is nothing experimental, is a logical decision in the current scientific knowledge," said Chantal Loire at Robert Debre Hospital in Paris, adding that "had never seen such a serious epidemic."

The epidemic broke out in Germany is caused by the bacterium Escherichia coli enterohaemorrhagic a rare type (E. coli O104: H4). The disease is most serious complication of hemolytic uremic syndrome (HUS), which is conventionally treated with transfusions or dialysis to compensate for deficiencies caused by toxins.

Soliris drug has a European marketing authorization in June 2007, is recommended for patients suffering from a rare disease (paroxysmal nocturnal hemoglobinuria), characterized by episodes of destruction of red blood cells.

"It is a revolutionary drug for this disease," said Dr. Veronique Frémeaux-Bacchi, from Georges Pompidou Hospital in Paris.

Today, German doctors evaluate drug use in patients with atypical hemolytic uremic syndrome, the infectious origin. "For these types of genetic data suggest that many would constitute an enormous progress. For about a year, the question of drug use for the most serious forms of hemolytic uremic syndrome (especially with extensions neurological), related to infection with E . Enterohaemorrhagic sheet, "said Loire.

New England Journal of Medicine recently published a study on the effectiveness of this drug for very severe forms of HUS of bacterial origin to three children in France, Canada and Germany.

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"It is very difficult to prove something in isolated cases, but even so, they risked their three children to die, but they had a favorable evolution," added the Loire.

The two French doctors said that the financial aspects of drug use - Soliris has been ranked as the most expensive medicine in the world, according to a ranking made by Forbes in 2010 - can not be taken into account. "If we do nothing, people either die or remain severely disabled or remain dependent on dialysis," said Loire.

The drug is used only in hospitals and precautions for use, including a pre-treatment mandatory vaccination.

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